Currently genomic characterization has become standard of care for tumor types such as non small cell lung cancer breast cancer melanoma and colorectal cancer a deep understanding of genomic alterations in different tumor types would help identify potentially actionable genomic changes which occur across a wide variety of tumor types a basket trial is a new type of clinical trial for . Evidence from the total programme of trials involves synthesis of the evidence from the individual trials see section 72 this is facilitated by ensuring that common standards are. In these cases sponsors remain responsible to conduct the trial in compliance with the protocol and with principles of good clinical practice clinical trials regulation art 47 ich e6r2 section 521. Investigators use adaptive trial designs to alter basic features of an ongoing trial this approach obtains the most information possible in an unbiased way while putting the fewest patients at ris. Common types of adaptive trials common types of adaptive clinical trials include but are not limited to sample size reassessment2 3 response adaptive randomisation and dropping of inferior treatment arms4 adaptive enrichment5 and seamless designs sample size reassessment uses event based evaluations during the trial to determine actual power3 6 response adaptive randomisation